Apologies for missing my appointment. I now know to call on Mondays and Wednesdays when I’m not having an episode to meet the same day.

I’m glad to report I’ve had success with Itraconozole combined with the medicines in my ‘stack’ in greatly reducing the number of episodes that I have

I’ve been having a back and forth with users on two forums  https://forums.phoenixrising.me/threads/pepcid-and-1-month-without-an-episode.92436/#post-2466773 and here https://www.healthrising.org/forums/threads/pepcid-and-1-month-without-an-episode.6893/#post-40788 I’ve also been posting details here under the ‘addendum’ https://www.notion.so/cfshelp/Overview-Page-cedcb4b9e91d4a01b62c6bfec26d2c2b

I’m running out of Itraconozole and would like a refill please, thanks in advance. I will call Monday, thanks,

The medicines in my ‘stack’ are as follows 1 pill Pepcid generic famotidin, a Zantac and alka Seltzer once a day, Itraconozole, Coffee, Kratom, PYM Attention focus chews, Albuterol and Alvesco

I’m still trying to get labwork done on days I neither have an episode nor pem and when the labs are open

There are many medicines I’m interested in, however I will wait until my experiment hits the 3month mark

The highlights of the posts are not required reading and are as follows

Month 1 By taking Pepcid I've had the first month free of an episode in years. I still have cfs (and with it pem, ibs, pots etc), however for the first time in years I've gone a month without an 'episode' (where I feel like I have the flu and have to sleep for between 3 days to three weeks). Without Pepcid I often have episodes lasting two to three days long (sometimes with only a day or two in between episodes). Up until now, 80 percent of episodes last two to three days, 10 percent of episodes go on about a week, and 7 percent go on two weeks. The longest I had was three weeks of only getting up to pee, hardly eating and dizzy when I do get up, and feeling awful like I have the flu. So I am very thankful for having found Pepcid. I say one month because I just came out of a two day episode. I will track and update the post next month where hopefully I found the same effects!

Month 2 had two episodes, but wasn't taking Itraconozole strictly

Month 3 :) I drove my fiance' and stepdaughter for a getaway 3 hours away in heavy traffic and slept the next day, however as mentioned earlier I restarted the Itraconozole with nasoneb as well as the 'stack' as you described it. In the afternoon the next day I was able to drive them around sightseeing as well as the day after that. Also at night I was waking up, working 4 or 5 hours, sleeping until the afternoon then driving them around.

This is generally unheard of since my CFS started 13 years ago. I wouldn't have even thought of taking my stepdaughter for a getaway much less doing it. I am happy to check in to say that, knock on wood, this 'stack' is working, and I believe the Itraconozole via Nasoneb is a crucial component of that. You will need a Drs prescription unless you use one of those lenient online pharmacies with Drs that prescribe you just about whatever you want within reason. I will check in again later and let you know, Thanks!

The positive roll keeps going! I wouldn't say this 'stack' (Itraconozole, Kratom, Pepcid etc) is a 'Silver Bullet', but it's at least a brass bullet! I drove my fiance and stepdaughter back to their home about 2hrs away and slept. Then instead of sleeping the next day, I woke at 4:45 am and drove to my place again 2hrs away, and instead of sleeping I had one of the most productive days in 13 years. I worked until noon, then napped until 4, got up and worked until sleeping. All the while I was concerned about not pushing myself to avoid pem the next day, so when I walked my guest and his dog instead of the full loop, I did half. Just having a guest was both unusual and a sign of a change in my state of wellbeing and attitude,

To reiterate, Yesterday was amazing, I had driven my fiance' and stepdaughter back to their home in the evening and slept, then instead of sleeping all day the next day I woke at 4:45am and drove, then worked until noon, slept until 4 then was clear to work until the evening. I ordered breakfast, made coffee, did light yardwork, cleaned and sorted my room, showered, shaved, took my medicines, ordered online, then when a guest I had been wanting to collaborate with said he would be nearby, arranged to meet around 5 something I would never have endeavor as I know I loose focus around that time and am asleep by 7, so he arrived, I interviewed him, took his buddee pet Willey for a walk, ordered dinner, picked up dinner, cleaned, emptied dishwasher, and called my fiance.

I was concerned I would have pem today and I did, I slept all through the night got up realised I couldn't work so went to sleep until 4:40pm, though when I got up and now I don't feel achey like the flu. So this week has been a resounding success, I have confidence to take things on I wouldn't have considered such as the vacation and the interview

For the first time in 13 years I have Hope, that's based on observation, a feeling of better not just hopeforhope Attached are pictures of the Itraconozole I use with Nasoneb, it was prescribed at my request by a private clinic and compounded by Koshlan pharm, contents and direction CSinusitis (itraconazole 50mg/mupirocin 5mg/EDTA 15mg/Budesonide 0.5mg compounding capsule compounding capsule Dissolve contents of capsule in 15mL of sterile 0.9% saline. Perfuse each nostril with half the contents of solution 1-2 times per

Day two of pem. As I said it's a 'brass' not a 'silver' bullet. Still though, I was well enough to write the post yesterday and today, which as you know with pem it's unlikely I would focus that much, also haven't had a full blown cfs episode since I decided to try strickly adhering to this 'stack'. So I still mark it as a success. Considering doubling the Itraconozole dose and or doing it twice a day instead of once. Also going to look into what else is on Dr Brewer's protocol. There are many supplements and medicines I will like to trial, however, I don't want to interfere with this experiment, I will give it another month or two. I've added pictures of some of the supplements and medicines I will like to audition hmmm, pretty much slept all day and night yesterday and all day today, perhaps it is an episode, I will check in later Up and about, so it was pem not an episode. I will be careful not to overdo it today. Also I've doubled the dose of Itraconozole. By the way, I picked up athletes foot 25 years ago at a public pool and tried everything to get rid of it, now my toes have gone back to normal, Itraconozole has healed that ** It is believed Pepcid helps those with cfs as an h2 histamine antagonist, which may give credence to the mast cell activation theorist camp, or at least to those with a subset of cfs experiencing mass cell activation.

H2 receptors are positively coupled to adenylate cyclase, which stimulates the production of cAMP, which then activates protein kinase A (PKA, which also has been singled out as problematic in a lot of cfs research

I have tried hundreds of different supplements, pills, and therapies and only two things have helped, Kratom of the green malay variety and Pepcid. I detail it all on my cfs info page